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All anticonvulsants interfere with folic acid metabolism and patients on anticonvulsants may become folic acid deficient and develop macrocytic anemia Folic acid deficiency has been associated with neural tube defects and other congenital malformations Folic acid supplementation (4 mg/day) should be begun before pregnancy if possible 1 Women with epilepsy should have preconception counseling regarding the optimal anticonvulsant during pregnancy, a switch to the least teratogenic drug and the least

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number of medications prescribed, and the lowest dose needed 2 Blood levels of anticonvulsants should be measured every trimester and prior to delivery to maintain a therapeutic range 3 Patients should be screened for neural tube defects and other fetal anomalies associated with anticonvulsants What is the effect of anticonvulsants on vitamin K levels Many of the anticonvulsants, particularly phenytoin, induce a deficiency of vitamin K-dependent clotting factors (II, VI, IX, X) This places the patient and her fetus at risk for hemorrhage The patient should receive vitamin K supplementation (10 mg/day) from week 36 until delivery, and the newborn should also receive an IM injection of vitamin K after delivery

Granuloma Inguinale (Donovanosis)

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Arcade games are still popular despite the prevalence of home video games, because the video arcade has a social aspect as well as a game-playing aspect It gives kids a place to go, play games, and hang around together without their parents Arcade machines are also common anywhere that kids might be stuck with nothing to do, such as airports and hotels, and they re popular moneymakers for resorts and theme parks as well The people who buy arcade games that is, the machines themselves are really only interested in one thing, the amount of money that they make in a given time Arcade game design is strongly driven by this consideration An arcade game should take no longer than three to ten minutes to play, and unlike its predecessor, the pinball machine, it gets harder as you play Arcade games also have to be reasonably easy to learn, although the machine can make a lot of money by making its players learn the hard way The designer has to carefully balance this if the game is too frustrating at first, people simply won t play it and the game will be a commercial failure; if it s too easy, people will be able to play for a long time without putting any more coins in In any case, it can t be the kind of game that requires a manual or much detailed explanation Arcade games are a special subset of video games in general, because there are so many constraints on their design Shigeru Miyamoto, who invented Donkey Kong (and with it the whole Mario universe), switched from arcade machines to console machines because he found the requirement to generate coin-drop to be too limiting Developers in the arcade game industry need many of the same talents and skills as in the retail game industry, but the two businesses are otherwise quite different Since arcade games are sold to arcade owners rather than to end users, they have separate trade shows and other professional events.

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What is granuloma inguinale A slow, progressive genital ulcerative disease that is primarily sexually transmitted It is most common in the developing world; it is rare in the United States Klebsiella granulomatis (previously known as Calymmatobacterium granulomatis), a gram-negative pleomorphic bacillus Large, painless, and spreading ulcers typically in the vulva area; the lesions are clean but have friable bases with raised, rolled margins that bleed easily They are typically beefy red in appearance and exude a malodorous discharge Inguinal lymphadenopathy is rare Donovan bodies (intracytoplasmic safety pin shaped organisms seen after Giemsa or Wright staining of tissue specimens) Doxycycline or trimethoprimsulfamethoxazole (Tetracycline is no longer recommended because of bacterial resistance)

Online games that is, games which can only be played online are a rapidly growing segment of the market People like the social interaction of playing with other

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